Selected Publications

A first in the world example of CyTOF being used for high-parameter single-cell resolution signalling analysis of chimeric antigen receptors and chimeric costimulatory receptors. Given our research interest in developing novel T-cell engineering strategies, this paper has been particularly important. We applied existing and developed new techniques for describing how synthetic constructs such as chimeric antigen receptors signal, providing a greater level of mechanistic detail at singe-cell resolution than was previously possible. This revealed high levels of autonomous signalling from CAR constructs but not from chimeric costimulatory receptors expressed in gamma-delta T-cells.

This paper exemplified chimeric costimulatory receptors expressed in gamma-delta T cells as a means of avoiding on-target off-tumour toxicity, which is a major problem in cancer immunotherapy. We co-invented this immunotherapeutic approach and were pleased to see our work highlighted in a further editorial commentaries.