Innate Immune Engineering at UCL-Great Ormond Street Institute of Child Health
The Fisher Lab designs and analyses novel, allogeneic cancer immunotherapies. Harnessing the power of evolutionarily ancient γδT cells we create platform technologies to help treat both children and adults. Our focus is on the treatment of solid cancers which remain the major unmet therapeutic need.
We design immunotherapeutics with the target in mind
Building on the lessions from the αβT cell field, we have developed highly efficient γδT cell engineering strategies which allow us to exploit the innate anti-cancer properties of this cellular chassis. This has allowed us to create safer, more versatile approaches which are tailor-made for the solid tumor context
Our methodology
Find out about our design approaches and how we analyse new constructs to determine not only whether but also how they work
Patient & Public Engagement
Science for patient benefit has to involve patients, even at the early preclinical stages. The Fisher Laboratory has an active patient/public engagement group who provide invaluable perspectives on new designs and ideas